Other Publications

I have maintained interests in yeast taxonomy, bacterial lipid transfer, deep mutational scanning, synthetic biology, and genome evolution. The below publications reflect these interests and the many fantastic collaborative projects I have been a part of.

Humanized yeasts

During my PhD I developed a histone humanized yeast model. We used this system to see how yeast evolve with human histones, what histone variants function in yeast (i.e., which variants functionally replace canonical histones), and what yeast kinetochore components are replaceable with human homologs.

• Haase MAB, Lazar-Stefanita L, Ólafsson G, Wudzinska A, Shen MJ, Truong DM, Boeke JD^@. macroH2A1 drives nucleosome dephasing and genome instability in histone humanized yeast. Cell Reports, 2024
• Ólafsson G^@, Haase MAB, Boeke JD^@. Humanization reveals pervasive incompatibility of yeast and human kinetochore components. G3: Genes Genomes Genetics, 2024
• Haase MAB, Ólafsson G, Flores RL, Boakye-Ansah E, Zelter A, Dickinson MS, Lazar-Stefanita L, Truong DM, Asbury CL, Davis TN, Boeke JD^@. DASH/Dam1 complex mutants stabilize ploidy in histone-humanized yeast by weakening kinetochore-microtubule attachments. EMBO Journal, 2023
• Lazar-Stefanita L^@, Haase MAB, Boeke JD^@. Humanized nucleosomes reshape replication initiation and rDNA/nucleolar integrity in yeast. BioRxiv, 2023

Synthetic genomics

During my PhD I also contributed to synthetic yeast genome project (Sc2.0).

• Lauer SL, Luo J, Lazar-Stefanita L, Zhang W, McCulloch LM, Fanfani V, Lobzaev E, Haase MAB, Easo N, Zhao Y, Yu F, Cai J, The Build-A-Genome class, Bader JS, Stracquadanio G, Boeke JD^@. Context-dependent neocentromere activity in synthetic yeast chromosome VIII. Cell Genomics, 2023
• Zhang W, Lazar-Stefanita L, Yamashita H, Shen MJ, Mitchell LA, Kurasawa H, Lobzaev E, Fanfani F, Haase MAB, Sun X, [...], Boeke JD^@. Manipulating the 3D organization of the largest synthetic yeast chromosome. Molecular Cell, 2023
• Lazar-Stefanita L, Luo J, Haase MAB, Zhang W, Boeke JD^@. Two differentially stable rDNA loci coexist on the same chromosome and form a single nucleolus. PNAS, 2023

Yeast Evolutionary Genomics and Taxonomy

I have continued interest on yeast evolutionary genomics.

• Haase MAB^@, Lazar-Stefanita L, Baudry L, Wudzinska A, Zhou X, Rokas A, Hittinger CT, Pfander B, Musacchio A, Boeke JD^@. Ancient co-option of LTR retrotransposons as yeast centromeres. Nature, 2026
• Haase MAB^@, Steenwyk JL, Boeke JD. Gene loss and cis-regulatory novelty shaped core histone gene evolution in the apiculate yeast Hanseniaspora uvarum. Genetics, 2024
• Opulente DA, LaBella AL, Harrison MC, Wolters JF, Liu C, Kominek J, Steenwyk JL, Stoneman HR, VanDenAvond J, Miller CR, Langdon QK, Silva M, Gonçalves C, Ubbelohde EJ, Li Y, Buh KV, Jarzyna M, Haase MAB, Rosa CA, ˇCadež N, Libkind D, DeVirgilio JH, Hulfachor AB, Kurtzman CP, Sampaio JP, Gonçalves P, Zhou X, Shen XX, Groenewald M, Rokas A^@, Hittinger CT^@ Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts. Science, 2024
• Opulente DA^@, Langdon QK, Jarzyna M, Buh KV, Haase MAB, Groenewald M, Hittinger CT^@. Taxogenomic analysis of a novel yeast species isolated from soil, Pichia galeolata sp. nov.. Yeast, 2023
• Spurley WJ, Fisher KJ, Langdon QK, Buh KV, Jarzyna M, Haase MAB, Moriarty RV, Rodriguez D, Sheddan A, Wright S, Sorlie L, Hulfachor AB, Opulente DA, Hittinger CT^@. Substrate, temperature, and geographical patterns among nearly 2,000 natural yeast isolates. Yeast, 2021
• O’Brien CE, Oliveira-Pacheco J, Cinnéide EO, Haase MAB, Hittinger CT, Rogers TR, Zaragoza O, Bond U, Butler G^@. Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples. PLOS Pathogens, 2021
• Haase MAB⁺, Kominek J⁺, Opulente DA, Shen X, LaBella AL, Zhou X, DeVirgilio J, Hulfachor AB, Kurtzman CP, Rokas A, Hittinger CT^@. Repeated horizontal gene transfer of GALactose metabolism genes violates Dollo’s law of irreversible loss. Genetics, 2021
• Dharampal PS, Diaz-Garcia L, Haase MAB, Zalapa J, Currie CR, Hittinger CT, Steffan SA^@. Microbial Diversity Associated with the Pollen Stores of Captive-Bred Bumble Bee Colonies. Insects, 2020
• Opulente DA, Langdon QK, Buh KV, Haase MAB, Sylvester K, Moriarty RV, Jarzyna M, Considine SL, Schneider RM, Hittinger CT^@. Pathogenic budding yeast Isolated outside of clinical settings. FEMS Yeast Research, 2019
• Shen X, Opulente DA, Kominek J, Zhou X, Steenwyk J, Buh KV, Haase MAB, Wisecaver JH, Wang M, Doering DT, Boudouris JT, Schneider RM, Langdon QK, Ohkuma M, Endoh R, Takashima M, Manabe R, Cadez N, Libkind D, Rosa CA, DeVirgilio J, Hulfachor AB, Groenewald M, Kurtzman CP^@, Hittinger CT^@, Rokas A^@. Tempo and mode of genome evolution in the budding yeast subphylum. Cell, 2018
• Haase MAB, Kominek J, Langdon QK, Kurtzman CP, Hittinger CT^@. Genome sequence and physiological analysis of Yamadazyma laniorum f.a. sp. nov. and a reevaluation of the apocryphal xylose fermentation of its sister species, Candida tenuis. FEMS Yeast Research, 2017

Others

During my time at NYU I also collaborated on developing a pipeline for deep mutational scanning of bacterial lipid transfer proteins and with structural biologists studying histone modifying complexes.

• Santarossa CC, Li Y, Yousef S, Hasdemir HS, Rodriguez CC, Haase MAB, Baek M, Coudray N, Pavek JG, Focke KN, Silverberg AL, Bautista C, Yeh J, Marty M, Baker D, Tajkhorshid E, Ekiert DC^@, Bhabha G^@. LetA defines a structurally distinct transporter family. Nature, 2026
• MacRae MR, Puvanendran D, Haase MAB, Coudray N, Kolich L, Lam C, Baek M, Bhabha G^@, Ekiert DC^@. Protein-protein interactions in the Mla lipid transport system probed by computational structure prediction and deep mutational scanning. JBC, 2023

@ = Corresponding Author

+ = Equal Authorship

For a complete list of publications, please see my CV or Google Scholar